A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry

Share the joy
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  

Shin-ichi Nakatsuka, Isao Taguchi, Tadasuke Nagatomo, Michiaki Yamane, Kenji Sugio, Ryuichi Yoshino, Kazuko Oku, Teruaki Nagano, Hayato Kimura, Kazuya Nakajo, Gaku Kawabata

CytoJournal 2012 9(1):11-11

Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR) because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.
(via Articles : CytoJournal as on April 30, 2012)


Share the joy
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
About Jana Sullinger

GYN Pathologist and Cytopathologist. Special interest in quality assessment and use of online social media in sharing educational information about cytology and quality.

Leave a Reply

Follow

Get every new post delivered to your Inbox

Join other followers:

s2Member®
%d bloggers like this: