Case Studies: Metastatic Colorectal Adenocarcinoma in Cervicovaginal Cytology

Metastatic colorectal adenocarcinoma in cervicovaginal cytology specimens confirmed by immunocytochemical stains on liquid base specimens: Two study cases with review of the literature

Muhammad Zulfiqar, Susan Liu, Dongping Shi, Shashi Madan, Suzanne Jacques, Laquita King, Vinod Shidham, Tamar Giorgadze

CytoJournal 2013 10(1):9-9

Only a few cases of adenocarcinoma (ACA) metastatic to the female lower genital tract diagnosed on cervicovaginal Pap smear have been reported during the past several decades. Both conventional and liquid based cytology (LBC) have limited sensitivity and specificity in diagnosing metastatic disease and immunocytochemical (ICC) staining may be needed for confirming the diagnosis. We present two cases of metastatic colorectal ACA diagnosed on cervicovaginal ThinPrep (TP) Pap smears, with one confirmed by ICC staining method. Recognition of extra-uterine malignancy in the cervicovaginal cytology specimen is critical for the disease diagnosis, prognosis, and the treatment. ICC staining performed on the residual LBC specimen is an important methodology to confirm the diagnosis.
(via Articles : CytoJournal as on May 20, 2013)

About Jana Sullinger

GYN Pathologist and Cytopathologist. Special interest in quality assessment and use of online social media in sharing educational information about cytology and quality.


  1. […] Case Studies: Metastatic Colorectal Adenocarcinoma in Cervicovaginal Cytology The Populist Cytologist™ […]

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