Characterization of gene expression and activated signaling pathways in solid-pseudopapillary neoplasm (SPN) of pancreas
Modern Pathology advance online publication, September 27 2013.
Authors: Minhee Park, Minhyung Kim, Daehee Hwang, Misun Park, Won Kyu Kim, Sang Kyum Kim, Jihye Shin, Eun Sung Park, Chang Moo Kang, Young-Ki Paik
& Hoguen Kim
In Brief: The authors characterize the neoplasm-specific gene expression in solid-pseudopapillary neoplasm (SPN) to pancreatic ductal carcinomas, neuroendocrine tumors, and non-neoplastic pancreatic tissues. Their results provide insight into molecular pathways involved in solid-pseudopapillary neoplasm tumorigenesis, and less epithelial differentiation than the other more common pancreatic tumors.
Solid-pseudopapillary neoplasm (SPN) is a rare neoplasm of the exocrine pancreas (1-2%), and occurs almost exclusively in females in the 2nd to 3rd decades of life. Although rare, understanding its molecular mechanisms is both “…important and advantageous”. Solid-pseudopapillary neoplasm, unlike the more common pancreatic adenocarcinomas, exhibits somatic mutations in exon 3 of CTNNB1, which encodes β-catenin. Alterations in KRAS, TP53, CDKN2A, and SMAD4 have not been reported in SPN.
This study demonstrated the activation of the Wnt/β-catenin, Hedgehog, and androgen receptor signaling pathways in SPN and identified SPN-specific mRNA and microRNA expression. The authors provide a diagram (figure 3) which details the gene expression signature changes leading to activated signaling pathways in SPN.
This article isn’t “light reading”, or at least not for me, but it does highlight the fantastic advances in molecular pathology/cytopathology that will only become more common. The item listed below under “Related Articles” may offer you a guide to cell signaling.
The Populist Cytologist